Is neglect of self-clearance biasing TB vaccine impact estimates?

Danny ScarponiRebecca A ClarkChathika Krishan WeerasuriyaJon EmeryRein M G J Houben Richard G White Nicky McCreesh

Published in: BMJ global health (2023)

Our work suggests that the neglect of self-clearance in mathematical models of tuberculosis vaccines does not result in substantially biased estimates of tuberculosis vaccine impact. It may, however, mean that we are slightly underestimating the relative advantages of vaccines that work in uninfected individuals only compared with those that work in infected individuals.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
hiv aids
hiv infected
emergency department
adverse drug
hepatitis c virus