Structural brain correlates of childhood trauma with replication across two large, independent community-based samples.
Rebecca A MaddenKimberley AtkinsonXueyi ShenClaire GreenRobert F HillaryEmma L HawkinsEmma SågeAnca-Larisa SanduGordon D WaiterChristopher McNeilMathew HarrisArchie I CampbellDavid J PorteousJennifer A MacfarlaneAlison MurrayDouglas SteeleLiana RomaniukStephen M LawrieAndrew M McIntoshHeather C WhalleyPublished in: European psychiatry : the journal of the Association of European Psychiatrists (2023)
Associations between childhood trauma and reduced global and regional brain volumes were found, across two independent UK cohorts, and at mega-analysis. This provides robust evidence for a lasting effect of childhood adversity on brain structure.