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Structural brain correlates of childhood trauma with replication across two large, independent community-based samples.

Rebecca A MaddenKimberley AtkinsonXueyi ShenClaire GreenRobert F HillaryEmma L HawkinsEmma SågeAnca-Larisa SanduGordon D WaiterChristopher McNeilMathew HarrisArchie I CampbellDavid J PorteousJennifer A MacfarlaneAlison MurrayDouglas SteeleLiana RomaniukStephen M LawrieAndrew M McIntoshHeather C Whalley
Published in: European psychiatry : the journal of the Association of European Psychiatrists (2023)
Associations between childhood trauma and reduced global and regional brain volumes were found, across two independent UK cohorts, and at mega-analysis. This provides robust evidence for a lasting effect of childhood adversity on brain structure.
Keyphrases
  • early life
  • white matter
  • resting state
  • childhood cancer
  • cerebral ischemia
  • blood brain barrier