Metal-Free Intermolecular Aminoarylation of Alkynes.

Pauline T G RabetScott BoydMichael F Greaney

Published in: Angewandte Chemie (International ed. in English) (2017)

A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.

Keyphrases

cancer therapy
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energy transfer
structure activity relationship
mass spectrometry
high resolution
structural basis
quantum dots