Andrographolide Suppresses Expressions of Coagulation and Fibrinolytic Inhibition-Related Factors in LPS-Induced Alveolar Epithelial Cell Type II via NF-κB Signal Pathway In Vitro.

Guixia YangXiang LiQing LiChuan XiaoHong QianHuilin YangFeng Shen

Published in: Intensive care research (2022)

Our data demonstrates that targeting AECII is the mechanism by which Andro ameliorates alveolar hypercoagulaiton and fibrinolytic inhibition via NF-κB pathway in ARDS. Andro is worth to be clinically further studied in ARDS treatment.

Keyphrases

lps induced
inflammatory response
acute respiratory distress syndrome
signaling pathway
extracorporeal membrane oxygenation
mechanical ventilation
electronic health record
cancer therapy
toll like receptor
big data
mouse model
pi k akt
oxidative stress
nuclear factor
drug delivery
data analysis
replacement therapy