Proteome and functional decline as platelets age in the circulation.
Harriet E AllanMelissa A HaymanSimone MarconeMelissa V ChanMatthew L EdinTania MaffucciAbhishek JoshiLaura MenkeMarilena CrescenteManuel MayrDarryl C ZeldinPaul C J ArmstrongTimothy David WarnerPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Our findings demonstrate changes in protein content are linked to alterations in function as platelets age. This work delineates physical and functional changes in platelets as they age and serves as a base to examine differences associated with altered mean age of platelet populations in conditions such as immune thrombocytopenia and diabetes.