Early structural brain development in infants exposed to HIV and antiretroviral therapy in utero in a South African birth cohort.
Catherine J WedderburnNynke A GroenewoldAnnerine RoosShunmay YeungJean-Paul FoucheAndrea Mary RehmanDiana M GibbKatherine L NarrHeather J ZarDan J SteinKirsten Ann DonaldPublished in: Journal of the International AIDS Society (2022)
Lower caudate and total grey matter volumes were found in infants who were HEU compared to HU in the first weeks of life, and maternal immunosuppression was associated with reduced volumes. These findings suggest that antenatal HIV exposure may impact early structural brain development and improved antenatal HIV management may have the potential to optimize neurodevelopmental outcomes of children who are HEU.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- hiv testing
- white matter
- pregnant women
- men who have sex with men
- hepatitis c virus
- resting state
- south africa
- young adults
- preterm birth
- functional connectivity
- type diabetes
- multiple sclerosis
- cerebral ischemia
- adipose tissue
- skeletal muscle
- weight gain
- insulin resistance
- risk assessment