Maternal Exposure to Stress During Covid-19 and Non-Syndromic Orofacial Clefts: A Cohort Retrospective Study.
Heba Jafar SabbaghMona Talal AlSharifFatma Dawood AbdulhameedAziza Johar AljoharSultan Musaad AlghamdiSultan Musaad AlghamdiNajla Sulaiman AlrejayeLatifa Yousef AlGudaibiBahaudbdin Ibraheem SalloutBadi Shoaib AlbaqawiEman Abdulbaset AlnamnakaniLougin Khalid BrekeitOsama Adel BasriManal Ibrahim AlmalikNorah Suliman Al SoqihAli Bakr AlshaikhAbdullah Jameel AburizizaFaisal Ali Al QahtaniBushra Musaad AlghamdiAsalah Khalid AlraddadiHadeel Hamza KhajaRana Abdullah AlamoudiPublished in: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (2024)
Along with an established risk associated with family history of birth defects, stressful life events may be a risk factor for NSOFC development. Beyond folic acid's known benefit, it may be that higher maternal health concerns contribute to increased protective health behaviors during pregnancy. Ongoing research is needed to specify the maternal risk factors for NSOFC.