Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting.
Daiki IkarashiShigehisa KitanoTakashi TsuyukuboKazumasa TakenouchiTakayuki NakayamaHiroko OnagiAsumi SakaguchiMakiko YamashitaHidenori MizugakiShigekatsu MaekawaRenpei KatoYoichiro KatoTamotsu SugaiTetsuya NakatsuraWataru ObaraPublished in: British journal of cancer (2021)
This comprehensive analysis of the immune microenvironment of a muscle-invasive bladder cancer specimen revealed that preexisting tumour-infiltrating proliferating CD8+ T cells and CD204+ cells are indicators of the response to neoadjuvant chemotherapy and that CD204+ cells can be considered an unfavourable prognostic factor in these patients.
Keyphrases
- neoadjuvant chemotherapy
- muscle invasive bladder cancer
- prognostic factors
- locally advanced
- induced apoptosis
- lymph node
- sentinel lymph node
- cell cycle arrest
- stem cells
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- rectal cancer
- signaling pathway
- squamous cell carcinoma
- peritoneal dialysis
- cell death
- radiation therapy
- oxidative stress
- endoplasmic reticulum stress
- early stage