A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.

Yukiko KimuraEisaku IwanagaKouta IwanagaShinya EndoYoshitaka InoueKenji TokunagaYousuke NagahataKyoko MasudaHiroshi KawamotoMasao Matsuoka

Published in: European journal of haematology (2020)

These results indicate that the CEBPA 3'-UTR DMR is a novel regulatory element of CEBPA related to myeloid/NK/T-cell lineage leukemogenesis. Transcriptional regulation of CEBPA by IKZF1 may provide a clue for understanding the fate determination of myeloid vs. NK/T-lymphoid progenitors.

Keyphrases

bone marrow
acute myeloid leukemia
dendritic cells
nk cells
transcription factor
acute lymphoblastic leukemia
single cell
immune response
molecularly imprinted