Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.

Li-Na XuanZhen-Xin HuZhen-Fu JiangCong ZhangXiao-Wan SunWen-Hua MingHui-Tao LiuRong-Fang QiaoLin-Jie ShenShao-Bo LiuGuan-Yu WangLin WenZhi-Lin LuanJian Yin

Published in: CNS neuroscience & therapeutics (2023)

PXR is involved in the recovery of motor function after SCI by regulating NRF2/HO-1 pathway.

Keyphrases

spinal cord
spinal cord injury
oxidative stress
pi k akt
signaling pathway
neuropathic pain
cell proliferation