Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells.

Arnold SiposKwang-Jin Kim Constantinos SioutasEdward D Crandall

Published in: International journal of molecular sciences (2019)

Interactions between NP and A549 cells involve complex cellular processes leading to lysosomal dysfunction, which may provide opportunities for improved nanoparticle-based therapeutic approaches to lung cancer management.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway
high glucose
iron oxide
endothelial cells
drug induced