IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer.

Hua LiaoXiaodan ChangLin GaoCuiping YeYujie QiaoLingyan XieJie LinShaoxi CaiHangming Dong

Published in: Journal of translational medicine (2023)

We found that IL-17A promoted NSCLC progression and inhibited autophagy through the ROS/Nrf2/p62 pathway leading to increased PD-L1 expression in cancer cells. Modulation of IL-17A may affect the therapeutic efficacy of immunotherapy.

Keyphrases

cell death
oxidative stress
small cell lung cancer
signaling pathway
advanced non small cell lung cancer