Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux.
Nachiket VartakGeorgia GuentherFlorian JolyAmruta Damle-VartakGudrun WibbeltJörns FickelSimone JörsBrigitte Begher-TibbeAdrian FriebelKasimir WansingAhmed GhallabMarie RosselinNoemie BoissierIrene Vignon-ClementelChristian HedbergFabian GeislerHeribert HoferPeter JansenStefan HoehmeDirk DrasdoJan G HengstlerPublished in: Hepatology (Baltimore, Md.) (2021)
The liver consists of a diffusion-dominated canalicular domain, where hepatocytes secrete small molecules and generate a concentration gradient and a flow-augmented ductular domain, where regulated water influx creates unidirectional advection that augments the diffusive flux.