Myoclonus in patients with COVID-19; findings of autoantibodies against brain structures in cerebral spinal fluid.

Covid-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, is described. Analysis of cerebral-spinal fluid from the cases using indirect immunohistochemistry revealed antibodies against rodent brain tissue and similarities in staining patterns were observed, indicating the presence of anti-neuronal IgG autoantibodies targeting astrocytes in hippocampus.