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Impact and outcomes of primary cytomegalovirus disease in seronegative abdominal solid organ transplant recipients of cytomegalovirus unexposed donors (D-/R-).

Margaret R JorgensonJillian L DescourouezDou-Yan YangLily N StalterGlen E LeversonSandesh ParajuliDidier A MandelbrotJeannina A SmithRobert R Redfield
Published in: Transplant infectious disease : an official journal of the Transplantation Society (2021)
D-/R- aSOTRs infrequently develop CMV, however, when it occurs, they present with disease manifestations similar to and graft outcomes inferior to D+/R- with CMV. Additionally, the majority of CMV disease in D-/R- occurs in the first 90 days after transplant, suggesting possible donor subclinical infection or transfusion source. The complicated course in D-/R- is likely caused by low clinical suspicion. Awareness of disease severity and aggressive upfront management may promote positive outcomes.
Keyphrases
  • epstein barr virus
  • type diabetes
  • sickle cell disease
  • kidney transplantation