Impact and outcomes of primary cytomegalovirus disease in seronegative abdominal solid organ transplant recipients of cytomegalovirus unexposed donors (D-/R-).
Margaret R JorgensonJillian L DescourouezDou-Yan YangLily N StalterGlen E LeversonSandesh ParajuliDidier A MandelbrotJeannina A SmithRobert R RedfieldPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2021)
D-/R- aSOTRs infrequently develop CMV, however, when it occurs, they present with disease manifestations similar to and graft outcomes inferior to D+/R- with CMV. Additionally, the majority of CMV disease in D-/R- occurs in the first 90 days after transplant, suggesting possible donor subclinical infection or transfusion source. The complicated course in D-/R- is likely caused by low clinical suspicion. Awareness of disease severity and aggressive upfront management may promote positive outcomes.