Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer.
Juha P VäyrynenJinming ZhangChen YuanAndressa Dias CostaHannah L WilliamsVicente Morales-OyarvideMai Chan LauDouglas A RubinsonRichard F DunneMargaret M KozakWenjia WangDiana Agostini-VulajMichael G DrageLauren BraisEmma ReillyOsama RahmaThomas ClancyJiping WangDavid C LinehanAndrew J AguirreCharles S FuchsLisa M CoussensDaniel T ChangAlbert C KoongAram F HezelShuji OginoJonathan A NowakBrian M WolpinPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
A diverse set of myeloid cells are present within the PDAC tumor microenvironment and are distributed heterogeneously across patient tumors. Not only the densities but also the spatial locations of myeloid immune cells are associated with patient outcomes, highlighting the potential role of spatially resolved myeloid cell subtypes as quantitative biomarkers for PDAC prognosis and therapy.