Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy.

Pratibha DwarkanathAlfa MuhihiChristopher R SudfeldBlair J WylieMolin WangNandita PerumalTinku ThomasShabani M KinyogoliMohamed BakariRyan FernandezJohn-Michael RajNdeniria O SwaiNirmala BuggiRani ShobhaMary M SandoChristopher P DugganHonorati M MasanjaAnura V KurpadAndrea B PembeWafaie W Fawzi

Published in: The New England journal of medicine (2024)

In these two trials, low-dose calcium supplementation was noninferior to high-dose calcium supplementation with respect to the risk of preeclampsia. It was noninferior with respect to the risk of preterm live birth in the trial in India but not in the trial in Tanzania. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT03350516; Clinical Trials Registry-India number, CTRI/2018/02/012119; and Tanzania Medicines and Medical Devices Authority Trials Registry number, TFDA0018/CTR/0010/5).

Keyphrases

low dose
high dose
clinical trial
phase iii
phase ii
study protocol
preterm birth
stem cell transplantation
gestational age
pregnancy outcomes
early onset
low birth weight
preterm infants