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Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B.

Jitender YadavSana IsmaeelAyub Qadri
Published in: Antimicrobial agents and chemotherapy (2020)
Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.
Keyphrases
  • drug resistant
  • multidrug resistant
  • gram negative
  • acinetobacter baumannii
  • escherichia coli
  • single molecule
  • drug induced
  • transcription factor
  • binding protein
  • amino acid
  • tissue engineering