Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells.

Eva J H F Voogd Nina DoornMarloes LeversJeannette HofmeijerMonica Frega

Published in: Journal of neural engineering (2023)

This indicates that extended differentiation protocols should be used to study neuronal characteristics and to model brain disorders with SH-SY5Y cells. We provided insights that may offer the basis for the utilization of SH-SY5Y cells as a more relevant neuronal model in the study of brain disorders.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
oxidative stress
white matter
signaling pathway
multiple sclerosis
endothelial cells
pi k akt