The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.

Carolin GabbertLeonie BlöbaumTheresa LüthInke R KönigAmke CaliebeSebastian KochBjörn-Hergen LaabsChristine KleinJoanne Trinh

Published in: medRxiv : the preprint server for health sciences (2023)

In our cohort, coffee, tobacco, aspirin, and PGS are independent predictors of PD AAO. Additionally, lifestyle factors seem to have a greater influence on AAO than common genetic risk variants with aspirin presenting the largest effect. External validation of our findings is needed.

Keyphrases

low dose
metabolic syndrome
weight loss
cardiovascular events
physical activity
cardiovascular disease
copy number
antiplatelet therapy
genome wide
type diabetes
case report
acute coronary syndrome
dna methylation
percutaneous coronary intervention
anti inflammatory drugs