Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.
Marie-Rose B S CrombagThomas P C DorloEllen van der PanAnoek van StratenAndries M BergmanNielka P van ErpJos H BeijnenAlwin D R HuitemaPublished in: Pharmaceutical research (2019)
In this cohort study, age significantly and independently affected docetaxel clearance, showing lower docetaxel clearance in elderly patients. In our cohort, mCRPC and mHSPC patients both had higher clearance than patients with other solid tumors.