P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension.
Lance N BensonKatherine S DeckChristoph J MoraYunping GuoTonya M RaffertyLin-Xi LiLu HuangJ Tucker AndrewsZhiqiang QinDaniel W TrottRobert S HooverYunmeng LiuShengyu MuPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Our findings suggest a novel mechanism by which CD8Ts are activated in hypertension to exacerbate salt retention and infer that the P2X7 receptor on CD8Ts may represent a new therapeutic target to attenuate T-cell-mediated immunopathology in hypertension.
Keyphrases