Kif17 phosphorylation regulates photoreceptor outer segment turnover.
Tylor R LewisSean R KundingerBrian A LinkChristine InsinnaJoseph C BesharsePublished in: BMC cell biology (2018)
Taken together, our data support a model in which phosphorylation of KIF17 promotes its photoreceptor outer segment localization and disc shedding, a process essential for photoreceptor maintenance and homeostasis. While disc shedding has been predominantly studied in the context of the mechanisms underlying phagocytosis of outer segments by the retinal pigment epithelium, this work implicates photoreceptor-derived signaling in the underlying mechanisms of disc shedding.