Eculizumab treatment in atypical hemolytic uremic syndrome: correlation between functional complement tests and drug levels.
Massimo CugnoValentina CaponeSamantha GriffiniElena GrovettiGiulia PintarelliLuigi PorcaroEmilio ClementiGianluigi ArdissinoPublished in: Journal of nephrology (2022)
In patients with aHUS on eculizumab maintenance treatment, complement activity measurement can be used as a proxy for circulating levels of the drug. Monitoring complement activity allows for safe tailoring of the frequency of eculizumab administration, thus avoiding excessive drug exposure while keeping the disease in remission.