Platelets fine-tune effector responses of naïve CD4 + T cells via platelet factor 4-regulated transforming growth factor β signaling.

Yanan MinLong HaoXinguang LiuShuai TanHui SongHao NiZi ShengNatalie JoossXuena LiuRickard E MalmströmYang SunJianguo LiuHua TangHao ZhangChunhong MaJun PengMing HouChunyang Li

Published in: Cellular and molecular life sciences : CMLS (2022)

Platelets exert context-dependent regulations on effector responses of Tn cells via PF4-TGFβ duet, suggesting new possibilities of platelet-targeted interventions of T cell immunity.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
induced apoptosis
regulatory t cells
dendritic cells
type iii
cell cycle arrest
air pollution
physical activity
signaling pathway
cancer therapy
immune response
cell proliferation
pi k akt