Early Life Exposure to Human Milk Oligosaccharides Reduces Allergic Response in a Murine Asthma Model.
Tahereh BozorgmehrRozlyn C T BoutinSarah E WoodwardKatherine DonaldJo May ChowRachael H BuckBarton Brett FinlayPublished in: Journal of immunology research (2023)
We propose a model in which orally administered HMOs delivered during early life shift the microbiota toward increased production of SCFAs, which dampens the allergic immune responses behind allergy and asthma. Overall, these data suggest the potential for HMO supplementation to protect infants against asthma development later in life, with possible benefits against additional atopic diseases such as eczema and food allergies.
Keyphrases
- air pollution
- early life
- lung function
- allergic rhinitis
- human milk
- atopic dermatitis
- chronic obstructive pulmonary disease
- immune response
- low birth weight
- human health
- preterm infants
- electronic health record
- big data
- dendritic cells
- toll like receptor
- cystic fibrosis
- inflammatory response
- infectious diseases
- preterm birth