Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples.

Patricia R BraunMai Tanaka-SahkerAubrey C ChanSydney S JellisonMason J KlisaresBenjamin W HingYaseen ShabbirLindsey N GaulYasunori NagahamaJulian RoblesJonathan T HeinzmanSayeh SabbaghEllyn M CramerGabrielle N DuncanKumi YukiLiesl N CloseBrian J DlouhyMatthew A HowardHiroto KawasakiKyle M SteinJames B PotashGen Shinozaki

Published in: Psychiatry and clinical neurosciences (2019)

High-dose synthetic glucocorticoid administration in the setting of a dental procedure was significantly associated with DNAm changes within buccal samples. These findings are consistent with prior findings of an influence of glucocorticoids on DNAm in humans.

Keyphrases

dna methylation
genome wide
high dose
nk cells
gene expression
low dose
copy number
oral health