The influence of atorvastatin, amlodipine and ethoxidol on ubiquinol and ubiquinone endogenous plasma concentrations in patients with chronic heart failure.

Vladlena I Zozina Svetlana Nikolaevna Kondratenko Evgenia V ShikhLiudmila M KrasnykhEvgeny S MelnikovVladimir G Kukes

Published in: Current drug metabolism (2023)

Amlodipine is able to neutralize the negative effect of atorvastin on the redox balance of CoQ10 in patients with CHF. An additional prescription of the antioxidant ethoxidol to standard therapy for patients with CHF was substantiated. Determination of the redox state of CoQ10 in plasma can be used to diagnose and assess the degree of oxidative stress in patients with cardiovascular diseases, as well as to assess the efficacy and safety of ongoing pharmacotherapy.

Keyphrases

metabolic syndrome
oxidative stress
cardiovascular risk factors
cardiovascular disease
hypertensive patients
dna damage
diabetic rats
anti inflammatory
type diabetes
ejection fraction
induced apoptosis
solid phase extraction
electron transfer
heat shock
liquid chromatography
heat stress