Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients.
Andrew H KarabaWeiqiang ZhouShuai LiTihitina Y AytenfisuTrevor S JohnstonOlivia AkindeYolanda EbyAura T AbedonJennifer L AlejoCaroline X QinElizabeth A ThompsonJacqueline M Garonzik-WangJoel N BlanksonAndrea L CoxJustin R BaileySabra L KleinAndrew S PekoszDorry L SegevAaron A R TobianWilliam A WerbelPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
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