Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition.

Kaiqiang LiLingling WuYili ChenYuanyuan LiQianni WangMin LiKe HaoWei ZhangShanshan JiangZhen Wang

Published in: Drug design, development and therapy (2020)

This study suggests that β-mangostin can inhibit cell proliferation and induce oxidative damage in cells. It is the first study to demonstrate that β-mangostin induces oxidative damage in glioma cells by inhibiting the PI3K/AKT/mTOR signaling pathway.

Keyphrases

signaling pathway
oxidative stress
induced apoptosis
cell proliferation
pi k akt
epithelial mesenchymal transition
cell cycle
cell death
endoplasmic reticulum stress