Impact of maternal methylenetetrahydrofolate reductase C677T polymorphism on intervillous and decidual pathology with pregnancy loss.

Tzvetozar R MehandjievNodoka M TennoYukiko NakuraTzanko P GeorgievRyoko MinekawaTetsu WakimotoKazuya MimuraMasahiro NakayamaKanae KawakamiTakeshi KanagawaTakuji TomimatsuTomio FujitaYoshihiro OnouchiMakoto TakeuchiTadashi KimuraItaru Yanagihara

Published in: The journal of obstetrics and gynaecology research (2018)

To our knowledge, this is the first study showing that the MTHFR C677T TT genotype and T allele are associated with severe intervillous and decidual pathologies in patients with pregnancy loss. Differences in pathologic grades of MTHFR C677T TT genotype could support the hypothesis that further periconceptional treatment for pregnancy loss could be customized depending on single nucleotide polymorphisms.

Keyphrases

pregnancy outcomes
preterm birth
healthcare
neoadjuvant chemotherapy
early onset
radiation therapy
locally advanced
lymph node
rectal cancer
replacement therapy