A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes.
Karen K ChungDaniel AltmannFrederik BarkhofKatherine MiszkielPeter A BrexJonathan O'RiordanMichael EbnerFerran PradosM Jorge CardosoTom VercauterenSebastien OurselinAlan ThompsonOlga CiccarelliDeclan T ChardPublished in: Annals of neurology (2019)
Thirty years after onset, in a largely untreated cohort, there was a divergence of MS outcomes; some people accrued substantial disability early on, whereas others ran a more favorable long-term course. These outcomes could, in part, be predicted by radiological findings from within 1 year of first presentation. ANN NEUROL 2020;87:63-74.