Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers.
Mohsen FathiLindsey CharleyLaurence J N CooperNavin VaradarajanDaniel D MeyerPublished in: bioRxiv : the preprint server for biology (2022)
We present an imaging platform that uses artificial intelligence (AI) to track thousands of individual cell-cell interactions within nanowell arrays. We apply this platform to quantify how the T cell component of adaptive immunity responds to infections. Our results show that T cells specific for a conserved epitope within the SARS-CoV-2 spike protein are serial killers that can rapidly eliminate virally infected targets. The ability to map the functional capacity of T cells and their ability to kill infected cells provides fundamental insights into the immunology of vaccines and recovery from infections.
Keyphrases
- artificial intelligence
- sars cov
- machine learning
- single cell
- big data
- deep learning
- cell therapy
- induced apoptosis
- transcription factor
- respiratory syndrome coronavirus
- high throughput
- high resolution
- stem cells
- cell cycle arrest
- high density
- mesenchymal stem cells
- monoclonal antibody
- cell proliferation
- amino acid
- binding protein