Impact of PCSK9, WDR12, CDKN2A, and CXCL12 Polymorphisms in Jordanian Cardiovascular Patients on Warfarin Responsiveness and Sensitivity.

Rasheed K Ibdah Laith Naser Al-Eitan Nasr N AlrabadiAyah Y AlmasriAdan H AlnaamnehRame H Khasawneh Mansour Abdullah Alghamdi

Published in: International journal of general medicine (2021)

Carriers of CXCL12 rs2862116 polymorphism had an increased risk to be warfarin extensive responders compared to those with no or only one polymorphism (P = 0.01). However, the presence of PCSK9 rs11206510 polymorphism affects the warfarin maintenance doses (P ˃ 0.0001).

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
oral anticoagulants
ejection fraction
newly diagnosed
prognostic factors
patient reported outcomes