Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity.
Sarka SalajkovaMichal SramekDavid MalinakFilip HavelKamil MusilekMarketa BenkovaOndrej SoukupPavla VasicovaLukas PrchalRafael DolezalZdenek HodnyJiri BartekMonika ZarskaKamil KucaPublished in: Journal of biophotonics (2019)
The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio- and chemo-therapy and the stimulation of anti-tumor immune response. However, as the cytotoxicity of the conventional alkanethiol-QAS compounds limits their utility in medicine, here we developed GNRs modified by novel highly hydrophilic cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain N,N,N-trimethyl-3,6,9,12,15-pentaoxaheptadecyl-17-sulfanyl-1-ammonium bromide (POSAB) showing insignificant cytotoxicity in the free state. Surface modification of GNRs by POSAB allowed to prepare nanoparticles with good stability in water, high cellular uptake and localization in lysosomes that are a promising alternative to alkanethiol-stabilized GNRs especially for biomedical applications.
Keyphrases
- cancer therapy
- ionic liquid
- immune response
- drug delivery
- photodynamic therapy
- liquid chromatography
- induced apoptosis
- cell cycle arrest
- helicobacter pylori infection
- signaling pathway
- solid phase extraction
- risk assessment
- dendritic cells
- combination therapy
- cell proliferation
- cell death
- helicobacter pylori
- climate change
- drug release
- mesenchymal stem cells
- human health
- high resolution
- tandem mass spectrometry
- inflammatory response
- replacement therapy