The sex-dependent impact of PER2 polymorphism on sleep and activity in a novel mouse model of cranial-irradiation-induced hypersomnolence.
Kendra A AdegbesanFrancesco Tomassoni ArdoriSudhirkumar YanpallewarSean P BradleyYogita ChudasamaElizabeth VeraNicole BricenoAmanda L KingLino TessarolloMark R GilbertVivian A GuedesDeeDee K SmartTerri S ArmstrongDorela D Shuboni-MulliganPublished in: Neuro-oncology advances (2023)
The PER2 rs934945 polymorphism had long-lasting behavioral effects associated with radiation toxicity, particularly in sleep in females and the activity of all animals. Our findings shed light on biological mechanisms underlying C-RIH.