Pathophysiology of MS damage and repair: linking cerebral hypoperfusion to the development of irreversible tissue loss in MS using MRI.
Daniele MascaliAlessandro VillaniAntonio M ChiarelliEmma BiondettiIlona LippAnna DigiovanniValeria PozzilliAlessandra S CaporaleMarianna G RispoliPaola AjdinajMaria D'ApolitoEleonora GrassoStefano L SensiKevin MurphyValentina TomassiniRichard J S WisePublished in: European journal of neurology (2023)
GM hypoperfusion occurs in MS and is associated with irreversible WM damage, thus suggesting that cerebral hypoperfusion may actively contribute and possibly precede neurodegeneration by hampering tissue repair abilities in MS.