Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.

Erik A WilliamsAjay RavindranathanRohit GuptaNicholas O SteversAbigail K SuwalaChibo HongSomang KimJimmy Bo YuanJasper WuJairo BarretoCalixto-Hope G LucasEmily ChanMelike PekmezciPhilip E LeBoitThaddeus MullyArie PerryAndrew BollenJessica Van ZiffleW Patrick DevineAlyssa T ReddyNalin GuptaKristen BasnetRobert MacaulayPatrick MalafronteHan LeeWilliam H YongKevin Jon WilliamsTareq A JuratliDouglas A MataRichard S P HuangMatthew C HiemenzDean C PavlickGarrett M FramptonTyler JanovitzJeffrey S RossSusan M ChangMitchel S BergerLine Jacques Jun S Song Joseph F Costello David A Solomon

Published in: Neuro-oncology (2023)

We thus speculate that SOX10 indel mutations drive a unique subtype of schwannomas by impeding proper differentiation of immature Schwann cells.

Keyphrases

transcription factor
induced apoptosis
stem cells
cell cycle arrest
public health
copy number
genome wide
signaling pathway
cell death
oxidative stress
gene expression