A Formal Synthesis of (+)-Hannokinol Using a Chiral Horner-Wittig Reagent.
Michael TaperaFederica BorghiJan Lukas Mayer-FiggeFabia MittendorfIbrahim-Ethem CelikAdrián Gómez-SuárezStefan F KirschPublished in: Molecules (Basel, Switzerland) (2024)
Herein, we report a concise and efficient formal synthesis of (+)-hannokinol. Key to this new strategy is the use of a chiral Horner-Wittig reagent, readily available from 2-deoxy-D-ribose, to introduce the chiral 1,3-diol motif.