Body, metabolic and renal changes following cross-sex estrogen/progestogen therapy in a rodent model simulating its use by transwomen.
J V Gusmão-SilvaD C K LichteneckerL G A FerreiraÍ GoisR ArgeriG N GomesMagnus Régios Dias-da-SilvaPublished in: Journal of endocrinological investigation (2022)
Cross-sex hormone therapy with E2EN/DHPA significantly modified body characteristics in male rats, producing a feminizing change without altering blood pressure or generating harmful metabolic parameters, but larger translational studies are still needed.