Treatment of cutaneous leishmaniasis with a sequential scheme of pentamidine and tamoxifen in an area with a predominance of Leishmania (Viannia) guyanensis: A randomised, non-inferiority clinical trial.
Silmara Navarro PenniniJorge Augusto de Oliveira GuerraPaula Frassinetti Bessa RebelloMarília Rosa Abtibol BernardinoLuigui Lima de CastroAntonio Alcirley da Silva BalieiroCynthia de Oliveira FerreiraAriani Batista NoronhaCamila Gurgel Dos Santos da SilvaAndré Luiz LeturiondoDenison Vital de JesusFelipe Jules de Araújo SantosAnette Chrusciak-TalhariMaria das Graças Vale Barbosa GuerraSinésio TalhariPublished in: Tropical medicine & international health : TM & IH (2023)
Although a 72% cure rate presented by the combination of tamoxifen and pentamidine was lower than in the control group that achieved a 100% cure, it is still a safe and is a clinically relevant result. It indicates that the therapeutic scheme evaluated may be a promising option for populations in remote areas, however it should be further studied, in order to include a larger number of patients.