Predictive capacity of immune-related adverse events and cytokine profiling in neoadjuvant immune checkpoint inhibitor trials for head and neck squamous cell carcinoma.

Angela E AlnemriSruti TekumallaAnnie E MorocoIoannis VathiotisMadalina TulucStacey K MardekianTingting ZhanDavid M CognettiJoseph M CurryAthanassios ArgirisAlban LinnenbachAndrew P SouthLarry A HarshyneJennifer M JohnsonAdam J Luginbuhl

Published in: Cancer medicine (2024)

irAEs are associated with response to neoadjuvant ICI therapy in HNSCC and can serve as clinical indicators for improved clinical outcomes. irAEs can be predicted by concentrations of several circulating cytokines prior to treatment.

Keyphrases

rectal cancer
locally advanced
lymph node
single cell
squamous cell carcinoma
stem cells
combination therapy
mesenchymal stem cells
cell therapy