Identification and Integrated Analysis of the miRNA-mRNA Regulatory Network in Lens from an H 2 O 2 -Induced Zebrafish Cataract Model.
Mu ZhangJiawei LuoXiaoqing ChenYanhua ChenPengfei LiGuowei ZhangHuaijin GuanPeirong LuPublished in: Current eye research (2022)
We identified several DEGs and constructed a miRNA-mRNA regulatory network related to the DNA repair process in a zebrafish cataract model. These genes participate in the oxidative stress response of lens epithelium cells and finally contribute to the formation of zebrafish cataracts. The hub DEGs and hub DEmiRs could be potential therapeutic targets for ARC.
Keyphrases
- dna repair
- bioinformatics analysis
- network analysis
- cataract surgery
- dna damage
- induced apoptosis
- transcription factor
- cell cycle arrest
- binding protein
- dna damage response
- genome wide
- gene expression
- oxidative stress
- cell death
- risk assessment
- signaling pathway
- endoplasmic reticulum stress
- cell proliferation
- endothelial cells