Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging.

Guang-Ping CaiYa-Lin LiuLi-Ping LuoYe XiaoTie-Jian JiangJian YuanMin Wang

Published in: Cell proliferation (2022)

Our findings demonstrated that Alkbh1 regulated BMSCs fate and bone-fat balance during skeletal aging and provided a potential target for the treatment of osteoporosis.

Keyphrases

bone marrow
cell fate
bone mineral density
mesenchymal stem cells
postmenopausal women
adipose tissue
stem cells
transcription factor
single molecule
soft tissue
combination therapy
risk assessment
circulating tumor cells