Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24.
Roshan A KarunamuniMinh-Phuong Huynh-LeChun C FanWesley ThompsonAsona J LuiMaria Elena MartinezBrent S RoseBrandon A MahalRosalind A EelesZsofia Kote-JaraiKenneth Ross MuirArtitaya Lophatananonnull nullCatherine M TangenPhyllis J GoodmanIan M ThompsonWilliam J BlotWei ZhengAdam S KibelBettina F DrakeOlivier CussenotGeraldine Cancel-TassinFlorence MenegauxThérèse TruongJong Y ParkHui-Yi LinJack A TaylorJeannette T BensenJames L MohlerElizabeth T H FonthamLuc MultignerPascal BlanchetLaurent BrureauMarc RomanaRobin J LeachEsther M JohnJay H FowkeWilliam S BushMelinda C AldrichDana C CrawfordJennifer CullenGyorgy PetrovicsMarie-Élise ParentJennifer J HuMaureen Sandersonnull nullIan G MillsOle Andreas AndreassenAnders M DaleTyler M SeibertPublished in: Prostate cancer and prostatic diseases (2021)
We identified PCs within 8q24 that were strongly associated with the performance of PHS46+African. Further research to improve the clinical utility of polygenic risk scores (or models) is needed to improve health outcomes for men of African ancestry.
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