Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis.
Ning WuTaohua YuanZhiXin YinXiaotian YuanJianfei SunZunqiu WuQilong ZhangCarl RedshawShenggang YangXiaotian DaiPublished in: Drug design, development and therapy (2022)
Through a network pharmacology approach and animal study, we predicted and validated the active compounds of SX and their potential targets for RA treatment. The results suggest that SX can markedly alleviate CIA rat by modulating the VEGF/PI3K/AKT signaling pathway, TNF-α signaling pathway, IL/NF-κB signaling pathway.
Keyphrases
- signaling pathway
- pi k akt
- rheumatoid arthritis
- molecular docking
- epithelial mesenchymal transition
- induced apoptosis
- cell cycle arrest
- cell proliferation
- oxidative stress
- disease activity
- combination therapy
- vascular endothelial growth factor
- immune response
- interstitial lung disease
- molecular dynamics simulations
- cell death
- idiopathic pulmonary fibrosis
- inflammatory response
- toll like receptor