First-in-maintenance therapy for localized high-grade osteosarcoma: an open-label phase I/II trial of the anti-PD-L1 antibody ZKAB001.

Yan Zhou Qing-Cheng Yang Yang Dong Tong Ji Bing Zhang Cheng Yang Shuier Zheng Lina Tang Chenliang Zhou Guowei Qian Yujing Huang Wenxi Yu Hongtao Li Yonggang Wang Aina He Zan Shen Weibin Zhang Yingqi Hua Hongyu Bai Jiayi Zhao Benjamin X Li Xiangrong Dai Jianjun Zhang Hai-Yan Hu Yang Yao

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Switching to maintenance using ZKAB001 showed an acceptable safety profile and provided preliminary evidence of clinical activity in localized osteosarcoma patients.

Keyphrases

high grade
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
clinical trial
low grade
prognostic factors
peritoneal dialysis
phase ii
patient reported