syn -Elimination of glutamylated threonine in lanthipeptide biosynthesis.
Raymond SarksianLingyang ZhuWilfred A van der DonkPublished in: Chemical communications (Cambridge, England) (2023)
Methyllanthionine (MeLan) containing macrocycles are key structural features of lanthipeptides. They are formed typically by anti -elimination of L-Thr residues followed by cyclization of L-Cys residues onto the ( Z )-dehydrobutyrine (Dhb) intermediates. In this report we demonstrate that the biosynthesis of lanthipeptides containing the D- allo -L-MeLan macrocycle such as the morphogenetic lanthipeptide SapT proceeds through ( E )-Dhb intermediates formed by net syn -elimination of L-Thr.
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