Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy.

Julia LoosSamantha SchmaulTheresa Marie NollMagdalena PaterkaMiriam SchillnerJulian T LöffelFrauke ZippStefan Bittner

Published in: Journal of neuroinflammation (2020)

The behavior of ex-Th17 cells in EAE lesions in vivo resembles Th1 rather than Th17 cells, underlining that their change in cytokine production is associated with functional phenotype alterations of these cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
mass spectrometry