Copper-Catalyzed Chemoselective Coupling of N -Dithiophthalimides and Alkyl Halides: Synthesis of Unsymmetrical Disulfides and Sulfides.

In this paper, we report an unprecedented copper-catalyzed disulfides or sulfides coupling reaction involving unactivated alkyl halides and N -dithiophthalimides. This reaction can be conducted under mild conditions using low-cost metal catalysts and exhibits high chemical selectivity and functional group compatibility, enabling the efficient assembly of various sulfides and disulfides.